December 21, 2025 5:42 AM EST

San Francisco 49ers vs Indianapolis Colts 12/22/2025

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The San Francisco 49ers are a solid favorite with a 65.0% chance to beat the Indianapolis Colts. Christian McCaffrey is projected for 56.0 rushing yards and a 15.0% chance of having at least 1 rushing TD. In the 35.0% of simulations where Indianapolis Colts wins, Philip Rivers averages 0.97 TD passes vs 0.25 interceptions, while in losses he has a ratio of 0.68 TDs to 0.38 interceptions. Jonathan Taylor averages 87.0 rushing yards and 0.85 rushing TDs when Indianapolis Colts wins and 63.0 yards and 0.43 TDs in losses. The San Francisco 49ers has a 25.0% chance of forcing more turnovers than they commit. Positive turnover margin helps them win 90.0% of the time.

CURRENT SEASON: We advise relying on these trends after the first 3 weeks of the season.

San Francisco 49ersATS RECORDIndianapolis ColtsATS RECORDATS EDGE
All Games 8-6-0All Games 8-5-1No Edge
Road Games 60-20-00Home Games 5-2-1 No Edge
When Favored 7-3-0When Underdog 3-1-1No Edge
Non-Division Opp 5-4-0Non-Division Opp 6-3-1No Edge
Opp .500+ Record 3-4-0Opp .500+ Record 3-4-1No Edge

LAST SEASON: We advise factoring for these trends for the first 3 to 6 weeks of the Current Season.

San Francisco 49ersATS RECORDIndianapolis ColtsATS RECORDATS EDGE
All Games 5-12-0All Games 8-8-1No Edge
Road Games 10-70-00Home Games 5-3-1 No Edge
When Favored 5-8-0When Underdog 5-4-1No Edge
Non-Division Opp 4-7-0Non-Division Opp 4-7-0No Edge
Opp Under .500 39-53-0Opp Under .500 57-44-14No Edge

OVER-UNDER TRENDS

San Francisco 49ersO-U-P RECORDIndianapolis ColtsO-U-P RECORDO-U EDGE
All Totals (O-U-P) 8-5-1All Totals (O-U-P) 7-6-1OVER
On Road 5-2-1At Home 4-2-1OVER
All Totals Last Season 11-6-0All Totals Last Season 9-8-0OVER
On Road Last Season 6-2-0At Home Last Season 5-3-0OVER

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