October 05, 2025 5:03 AM EST

New England Patriots vs Buffalo Bills 10/05/2025

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The Buffalo Bills are a solid favorite with a 74.0% chance to beat the New England Patriots. James Cook is projected for 86.0 rushing yards and a 63.0% chance of having at least 1 rushing TD. In the 26.0% of simulations where New England Patriots wins, Drake Maye averages 1.6 TD passes vs 0.47 interceptions, while in losses he has a ratio of 1.06 TDs to 0.9 interceptions. TreVeyon Henderson averages 109.0 rushing yards and 1.43 rushing TDs when New England Patriots wins and 61.0 yards and 0.65 TDs in losses. The Buffalo Bills has a 72.0% chance of forcing more turnovers than they commit. Positive turnover margin helps them win 86.0% of the time.

CURRENT SEASON: We advise relying on these trends after the first 3 weeks of the season.

New England PatriotsATS RECORDBuffalo BillsATS RECORDATS EDGE
All Games 2-2-0All Games 2-2-0No Edge
Road Games 10-00-00Home Games 1-2-0New England Patriots
When Underdog 1-1-0When Favored 1-2-0No Edge
Division Opp 1-0-0Division Opp 1-1-0New England Patriots
Opp .500+ Record 0-1-0Opp .500+ Record 0-0-0No Edge

LAST SEASON: We advise factoring for these trends for the first 3 to 6 weeks of the Current Season.

New England PatriotsATS RECORDBuffalo BillsATS RECORDATS EDGE
All Games 7-9-1All Games 12-7-1No Edge
Road Games 40-50-00Home Games 7-2-0 No Edge
When Underdog 7-8-1When Favored 9-5-1No Edge
Division Opp 3-3-0Division Opp 3-3-0No Edge
Opp .500+ Record 43-54-12Opp Under .500 86-49-7No Edge

OVER-UNDER TRENDS

New England PatriotsO-U-P RECORDBuffalo BillsO-U-P RECORDO-U EDGE
All Totals (O-U-P) 2-2-0All Totals (O-U-P) 3-1-0OVER
On Road 1-0-0At Home 3-0-0OVER
All Totals Last Season 11-6-0All Totals Last Season 13-6-1OVER
On Road Last Season 4-5-0At Home Last Season 7-2-1OVER

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