September 16, 2025 1:14 PM EST

Chicago Cubs vs Pittsburgh Pirates 9/16/2025

AccuScore.com Game Forecast Preview  
Save 10% off membership by using coupon code: PREVIEW

The Pittsburgh Pirates are 42-34 at home this season and the Chicago Cubs are 40-35 on the road this season. This is a close match-up with both teams having a 45 to 55 percent chance of winning based on 10,000 game simulations generated one play at a time by the AccuScore Simulation Supercomputer. Both starters have a good chance of having a quality start. Paul Skenes has a 59% chance of a QS and Cade Horton a 56% chance. If Paul Skenes has a quality start the Pirates has a 63% chance of winning. His simulated strikeout to walk ratio is 5 and he has a 38% chance of having a 5 to 1 K/BB ratio. When he has a 5/1 ratio the Pirates win 46%. If Cade Horton has a quality start the Cubs has a 72% chance of winning. His simulated strikeout to walk ratio is 3.4 and he has a 24% chance of having a 5 to 1 K/BB ratio. When he has a 5/1 ratio the Cubs win 55%. In simulations we tracked the batter for each team that was most productive based his average hits, walks and RBI per simulation. The most productive batter for the Pittsburgh Pirates is Tommy Pham who averaged 1.92 hits+walks+RBI. He has a 29% chance of having a big game with 3+ Hits, Walks, RBI and if he has a big game the Pirates have a 64% chance of winning. The most productive batter for the Chicago Cubs is Seiya Suzuki who averaged 1.88 hits+walks+RBI. He has a 29% chance of having a big game with 3+ Hits, Walks, RBI and if he has a big game the Cubs have a 71% chance of winning.

CURRENT SEASON: We advise relying on these trends after the first 6 to 8 weeks of the season. UNITS EDGE FAVORS: Chicago Cubs

Chicago CubsRECORDPittsburgh PiratesRECORDUNITS EDGE
Record on the Road40-35, 53% 98Record at Home42-34, 55% 796Pittsburgh Pirates
VS Pittsburgh Pirates8-3, 73% 218VS Chicago Cubs3-8, 27% -394Chicago Cubs
vs Team Under .50050-25, 67% 658vs Team .500 or Better37-53, 41% -468Chicago Cubs
Record As Road Underdog14-17, 45% 15Record As Home Favorite15-15, 50% -493Chicago Cubs
When Cade Horton Starts10-6, 62% 85When Paul Skenes Starts15-15, 50% -244Chicago Cubs

PAST 30 DAYS: We advise incorporating these trends along with the current Season after the first 6 to 8 weeks. UNITS EDGE FAVORS: Pittsburgh Pirates

Chicago CubsRECORDPittsburgh PiratesRECORDUNITS EDGE
Record on the Road8-5, 62% 107Record at Home8-5, 62% 252Pittsburgh Pirates
VS Pittsburgh Pirates2-0, 100% 132VS Chicago Cubs0-2, 0% -200Chicago Cubs
vs Team Under .50017-7, 71% 507vs Team .500 or Better7-7, 50% 154Chicago Cubs
Record As Road Underdog1-0, 100% 140Record As Home Favorite3-0, 100% 143Pittsburgh Pirates
When Cade Horton Starts3-1, 75% 101When Paul Skenes Starts4-1, 80% 214Pittsburgh Pirates

OVER-UNDER TRENDS

Chicago CubsRECORDPittsburgh PiratesRECORDO-U EDGE
OVER-UNDER ON ROAD35-37, 49% OverOVER-UNDER AT HOME31-39, 44% OverUNDER
ROAD OVER-UNDER PAST 30 DAYS3-9, 25% OverROAD OVER-UNDER PAST 30 DAYS5-7, 42% OverUNDER
ROAD OVER-UNDER LAST SEASON40-36, 53% OverROAD OVER-UNDER LAST SEASON43-38, 53% OverUNDER
OVER-UNDER IN Cade Horton STARTS5-10, 33% OverOVER-UNDER IN Paul Skenes STARTS10-17, 37% OverN/A

ACCUSCORE ADVISOR: AccuScore simulates every game thousands of times one play at a time. We are the industry standard in sports forecasting and the only company to be paid for sports picks and predictions by the biggest sports companies in the world. Our newest product, the AccuScore Advisor, provides Side Value, Money Line and Over-Under picks for every MLB game and rates them as One, Two, Three or Four Star picks. Three and Four Star picks have delivered over +10,000 units of profit the past 2 seasons. Visit AccuScore.com to find out what AccuScore\'s Advisor recommends for this game. The following trends are AccuScore\'s RIGHT-WRONG records and units (+/-) when making picks involving these teams.

SIDE VALUE (Current Season) - Chicago Cubs Road Games: 38-37, 51% -1017 Pittsburgh Pirates Home Games: 36-40, 47% -227 SIDE VALUE (PAST 30 DAYS) - Chicago Cubs Road Games: 7-6, 54% -178 Pittsburgh Pirates Home Games: 4-9, 31% -481

MONEY LINE (Current Season) - Chicago Cubs Road Games: 43-32, 57% +117 Pittsburgh Pirates Home Games: 40-36, 53% -414 MONEY LINE (PAST 30 DAYS) - Chicago Cubs Road Games: 10-3, 77% +471 Pittsburgh Pirates Home Games: 8-5, 62% -19

OVER-UNDER RECORD (Current Season) - Chicago Cubs Road Games: 40-22, 65% + 1580 Pittsburgh Pirates Home Games: 32-32, 50% -320 OVER-UNDER RECORD (PAST 30 DAYS) - Chicago Cubs Road Games: 7-4, 64% + 260 Pittsburgh Pirates Home Games: 7-4, 64% + 260

Click here to see AccuScore's pick for this game

Save 10% off membership by using coupon code: PREVIEW