August 21, 2025 4:38 AM EST

San Francisco Giants vs San Diego Padres 8/21/2025

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The San Diego Padres are 40-21 at home this season and are heavy favorites to beat the San Francisco Giants who are 31-33 on the road this season. The Padres have a better than 60% chance of winning based on 10,000 game simulations generated one play at a time by the AccuScore Simulation Supercomputer. Padres starter Dylan Cease is forecasted to have a better game than Giants starter Justin Verlander. Dylan Cease has a 56% chance of having a Quality Start (QS) while Justin Verlander has a 34% chance of a QS. If Dylan Cease has a quality start the Padres has a 81% chance of winning. His simulated strikeout to walk ratio is 4.4 and he has a 27% chance of having a 5 to 1 K/BB ratio. When he has a 5/1 ratio the Padres win 68%. In Justin Verlander quality starts the Giants win 57%. He has a 21% chance of having a 5 to 1 K/BB ratio and if he does his team wins 57% of simulations. In simulations we tracked the batter for each team that was most productive based his average hits, walks and RBI per simulation. The most productive batter for the San Diego Padres is Manny Machado who averaged 2.36 hits+walks+RBI. He has a 40% chance of having a big game with 3+ Hits, Walks, RBI and if he has a big game the Padres have a 79% chance of winning. The most productive batter for the San Francisco Giants is Rafael Devers who averaged 2.17 hits+walks+RBI. He has a 36% chance of having a big game with 3+ Hits, Walks, RBI and if he has a big game the Giants have a 46% chance of winning.

CURRENT SEASON: We advise relying on these trends after the first 6 to 8 weeks of the season. UNITS EDGE FAVORS: San Diego Padres

San Francisco GiantsRECORDSan Diego PadresRECORDUNITS EDGE
Record on the Road31-33, 48% -334Record at Home40-21, 66% 868San Diego Padres
VS San Diego Padres3-9, 25% -601VS San Francisco Giants9-3, 75% 536San Diego Padres
vs Team .500 or Better31-37, 46% -778vs Team Under .50047-25, 65% 1287San Diego Padres
Record As Road Underdog17-19, 47% 124Record As Home Favorite31-16, 66% 383San Diego Padres
When Justin Verlander Starts6-16, 27% -1006When Dylan Cease Starts12-11, 52% -267San Diego Padres

PAST 30 DAYS: We advise incorporating these trends along with the current Season after the first 6 to 8 weeks. UNITS EDGE FAVORS: San Diego Padres

San Francisco GiantsRECORDSan Diego PadresRECORDUNITS EDGE
Record on the Road7-4, 64% 348Record at Home9-3, 75% 322San Francisco Giants
VS San Diego Padres1-5, 17% -377VS San Francisco Giants5-1, 83% 281San Diego Padres
vs Team .500 or Better5-9, 36% -402vs Team Under .50014-5, 74% 633San Diego Padres
Record As Road Underdog5-3, 62% 319Record As Home Favorite8-3, 73% 218San Francisco Giants
When Justin Verlander Starts1-4, 20% -252When Dylan Cease Starts3-2, 60% -3San Diego Padres

OVER-UNDER TRENDS

San Francisco GiantsRECORDSan Diego PadresRECORDO-U EDGE
OVER-UNDER ON ROAD35-27, 56% OverOVER-UNDER AT HOME27-34, 44% OverOVER
ROAD OVER-UNDER PAST 30 DAYS6-5, 55% OverROAD OVER-UNDER PAST 30 DAYS7-5, 58% OverOVER
ROAD OVER-UNDER LAST SEASON45-31, 59% OverROAD OVER-UNDER LAST SEASON43-37, 54% OverUNDER
OVER-UNDER IN Justin Verlander STARTS8-13, 38% OverOVER-UNDER IN Dylan Cease STARTS11-10, 52% OverN/A

ACCUSCORE ADVISOR: AccuScore simulates every game thousands of times one play at a time. We are the industry standard in sports forecasting and the only company to be paid for sports picks and predictions by the biggest sports companies in the world. Our newest product, the AccuScore Advisor, provides Side Value, Money Line and Over-Under picks for every MLB game and rates them as One, Two, Three or Four Star picks. Three and Four Star picks have delivered over +10,000 units of profit the past 2 seasons. Visit AccuScore.com to find out what AccuScore\'s Advisor recommends for this game. The following trends are AccuScore\'s RIGHT-WRONG records and units (+/-) when making picks involving these teams.

SIDE VALUE (Current Season) - San Francisco Giants Road Games: 27-37, 42% -1016 San Diego Padres Home Games: 29-32, 48% -94 SIDE VALUE (PAST 30 DAYS) - San Francisco Giants Road Games: 5-6, 45% +52 San Diego Padres Home Games: 5-7, 42% -194

MONEY LINE (Current Season) - San Francisco Giants Road Games: 34-30, 53% -414 San Diego Padres Home Games: 33-28, 54% -482 MONEY LINE (PAST 30 DAYS) - San Francisco Giants Road Games: 7-4, 64% +116 San Diego Padres Home Games: 6-6, 50% -187

OVER-UNDER RECORD (Current Season) - San Francisco Giants Road Games: 25-26, 49% -360 San Diego Padres Home Games: 30-20, 60% + 800 OVER-UNDER RECORD (PAST 30 DAYS) - San Francisco Giants Road Games: 4-4, 50% -40 San Diego Padres Home Games: 5-3, 62% + 170

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