June 25, 2025 5:45 AM EST

Chicago Cubs vs St. Louis Cardinals 6/25/2025

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The Chicago Cubs are 21-18 on the road this season and are heavy favorites to beat the St. Louis Cardinals who are 25-15 at home. The Cubs have a better than 55% chance of winning based on 10,000 game simulations generated one play at a time by the AccuScore Simulation Supercomputer. Cubs starter Matthew Boyd is forecasted to have a better game than Cardinals starter Erick Fedde. Matthew Boyd has a 52% chance of having a Quality Start (QS) while Erick Fedde has a 44% chance of a QS. If Matthew Boyd has a quality start the Cubs has a 75% chance of winning. His simulated strikeout to walk ratio is 3.7 and he has a 31% chance of having a 5 to 1 K/BB ratio. When he has a 5/1 ratio the Cubs win 60%. In Erick Fedde quality starts the Cardinals win 66%. He has a 17% chance of having a 5 to 1 K/BB ratio and if he does his team wins 66% of simulations. In simulations we tracked the batter for each team that was most productive based his average hits, walks and RBI per simulation. The most productive batter for the St. Louis Cardinals is Ivan Herrera who averaged 2.08 hits+walks+RBI. He has a 34% chance of having a big game with 3+ Hits, Walks, RBI and if he has a big game the Cardinals have a 58% chance of winning. The most productive batter for the Chicago Cubs is Kyle Tucker who averaged 2.43 hits+walks+RBI. He has a 42% chance of having a big game with 3+ Hits, Walks, RBI and if he has a big game the Cubs have a 72% chance of winning.

CURRENT SEASON: We advise relying on these trends after the first 6 to 8 weeks of the season. UNITS EDGE FAVORS: St. Louis Cardinals

Chicago CubsRECORDSt. Louis CardinalsRECORDUNITS EDGE
Record on the Road21-18, 54% 202Record at Home25-15, 62% 818St. Louis Cardinals
VS St. Louis Cardinals0-2, 0% -200VS Chicago Cubs2-0, 100% 191St. Louis Cardinals
vs Team .500 or Better24-27, 47% -509vs Team .500 or Better23-21, 52% 227St. Louis Cardinals
Record as Road Favorite13-7, 65% 286Record as Home Underdog13-8, 62% 654St. Louis Cardinals
When Matthew Boyd Starts7-8, 47% -377When Erick Fedde Starts6-9, 40% -224St. Louis Cardinals

PAST 30 DAYS: We advise incorporating these trends along with the current Season after the first 6 to 8 weeks. UNITS EDGE FAVORS: St. Louis Cardinals

Chicago CubsRECORDSt. Louis CardinalsRECORDUNITS EDGE
Record on the Road4-7, 36% -379Record at Home6-7, 46% -149St. Louis Cardinals
VS St. Louis Cardinals0-2, 0% -200VS Chicago Cubs2-0, 100% 191St. Louis Cardinals
vs Team .500 or Better5-8, 38% -423vs Team .500 or Better10-11, 48% -193St. Louis Cardinals
Record as Road Favorite3-3, 50% -78Record as Home Underdog3-4, 43% -53St. Louis Cardinals
When Matthew Boyd Starts2-3, 40% -232When Erick Fedde Starts2-3, 40% -77St. Louis Cardinals

OVER-UNDER TRENDS

Chicago CubsRECORDSt. Louis CardinalsRECORDO-U EDGE
OVER-UNDER ON ROAD23-15, 61% OverOVER-UNDER AT HOME22-17, 56% OverOVER
ROAD OVER-UNDER PAST 30 DAYS5-6, 45% OverROAD OVER-UNDER PAST 30 DAYS8-5, 62% OverOVER
ROAD OVER-UNDER LAST SEASON40-36, 53% OverROAD OVER-UNDER LAST SEASON38-43, 47% OverOVER
OVER-UNDER IN Matthew Boyd STARTS6-8, 43% OverOVER-UNDER IN Erick Fedde STARTS6-8, 43% OverN/A

ACCUSCORE ADVISOR: AccuScore simulates every game thousands of times one play at a time. We are the industry standard in sports forecasting and the only company to be paid for sports picks and predictions by the biggest sports companies in the world. Our newest product, the AccuScore Advisor, provides Side Value, Money Line and Over-Under picks for every MLB game and rates them as One, Two, Three or Four Star picks. Three and Four Star picks have delivered over +10,000 units of profit the past 2 seasons. Visit AccuScore.com to find out what AccuScore\'s Advisor recommends for this game. The following trends are AccuScore\'s RIGHT-WRONG records and units (+/-) when making picks involving these teams.

SIDE VALUE (Current Season) - Chicago Cubs Road Games: 18-21, 46% -821 St. Louis Cardinals Home Games: 21-19, 52% +63 SIDE VALUE (PAST 30 DAYS) - Chicago Cubs Road Games: 7-4, 64% -57 St. Louis Cardinals Home Games: 3-10, 23% -723

MONEY LINE (Current Season) - Chicago Cubs Road Games: 21-18, 54% -160 St. Louis Cardinals Home Games: 24-16, 60% +392 MONEY LINE (PAST 30 DAYS) - Chicago Cubs Road Games: 9-2, 82% +489 St. Louis Cardinals Home Games: 5-8, 38% -403

OVER-UNDER RECORD (Current Season) - Chicago Cubs Road Games: 23-14, 62% + 760 St. Louis Cardinals Home Games: 19-16, 54% + 140 OVER-UNDER RECORD (PAST 30 DAYS) - Chicago Cubs Road Games: 3-7, 30% -470 St. Louis Cardinals Home Games: 3-7, 30% -470

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