June 21, 2025 9:29 AM EST

Cleveland Guardians vs Athletics 6/21/2025

AccuScore.com Game Forecast Preview  
Save 10% off membership by using coupon code: PREVIEW

The Athletics are 15-25 at home this season and are solid favorites to beat the Cleveland Guardians who are 18-21 on the road this season. The Athletics have a better than 55% chance of winning based on 10,000 game simulations generated one play at a time by the AccuScore Simulation Supercomputer. Athletics starter JP Sears is forecasted to have a better game than Guardians starter Luis Ortiz. JP Sears has a 49% chance of having a Quality Start (QS) while Luis Ortiz has a 42% chance of a QS. If JP Sears has a quality start the Athletics has a 76% chance of winning. His simulated strikeout to walk ratio is 4.3 and he has a 37% chance of having a 5 to 1 K/BB ratio. When he has a 5/1 ratio the Athletics win 57%. In Luis Ortiz quality starts the Guardians win 66%. He has a 24% chance of having a 5 to 1 K/BB ratio and if he does his team wins 66% of simulations. In simulations we tracked the batter for each team that was most productive based his average hits, walks and RBI per simulation. The most productive batter for the Athletics is Jacob Wilson who averaged 2.61 hits+walks+RBI. He has a 47% chance of having a big game with 3+ Hits, Walks, RBI and if he has a big game the Athletics have a 67% chance of winning. The most productive batter for the Cleveland Guardians is Jose Ramirez who averaged 2.69 hits+walks+RBI. He has a 47% chance of having a big game with 3+ Hits, Walks, RBI and if he has a big game the Guardians have a 58% chance of winning.

CURRENT SEASON: We advise relying on these trends after the first 6 to 8 weeks of the season. UNITS EDGE FAVORS: Athletics

Cleveland GuardiansRECORDAthleticsRECORDUNITS EDGE
Record on the Road18-21, 46% -110Record at Home15-25, 38% -850Cleveland Guardians
VS Athletics0-1, 0% -100VS Cleveland Guardians1-0, 100% 104Athletics
vs Team Under .50012-7, 63% 240vs Team .500 or Better16-33, 33% -1249Cleveland Guardians
Record as Road Favorite4-6, 40% -264Record as Home Underdog13-16, 45% -35Athletics
When Luis Ortiz Starts5-10, 33% -451When Mitch Spence Starts7-6, 54% 177Athletics

PAST 30 DAYS: We advise incorporating these trends along with the current Season after the first 6 to 8 weeks. UNITS EDGE FAVORS: Athletics

Cleveland GuardiansRECORDAthleticsRECORDUNITS EDGE
Record on the Road6-8, 43% -29Record at Home7-9, 44% -17Athletics
VS Athletics0-1, 0% -100VS Cleveland Guardians1-0, 100% 104Athletics
vs Team Under .5002-5, 29% -397vs Team Under .5005-7, 42% -41Athletics
Record as Road Favorite0-1, 0% -100Record as Home Underdog7-8, 47% 83Athletics
When Luis Ortiz Starts2-4, 33% -112When Mitch Spence Starts3-1, 75% 338Athletics

OVER-UNDER TRENDS

Cleveland GuardiansRECORDAthleticsRECORDO-U EDGE
OVER-UNDER ON ROAD15-21, 42% OverOVER-UNDER AT HOME24-15, 62% OverOVER
ROAD OVER-UNDER PAST 30 DAYS2-11, 15% OverROAD OVER-UNDER PAST 30 DAYS8-7, 53% OverUNDER
ROAD OVER-UNDER LAST SEASON31-49, 39% OverROAD OVER-UNDER LAST SEASON39-42, 48% OverOVER
OVER-UNDER IN Luis Ortiz STARTS7-8, 47% OverOVER-UNDER IN Mitch Spence STARTS7-6, 54% OverN/A

ACCUSCORE ADVISOR: AccuScore simulates every game thousands of times one play at a time. We are the industry standard in sports forecasting and the only company to be paid for sports picks and predictions by the biggest sports companies in the world. Our newest product, the AccuScore Advisor, provides Side Value, Money Line and Over-Under picks for every MLB game and rates them as One, Two, Three or Four Star picks. Three and Four Star picks have delivered over +10,000 units of profit the past 2 seasons. Visit AccuScore.com to find out what AccuScore\'s Advisor recommends for this game. The following trends are AccuScore\'s RIGHT-WRONG records and units (+/-) when making picks involving these teams.

SIDE VALUE (Current Season) - Cleveland Guardians Road Games: 21-18, 54% +386 Athletics Home Games: 17-23, 42% -660 SIDE VALUE (PAST 30 DAYS) - Cleveland Guardians Road Games: 7-7, 50% +116 Athletics Home Games: 6-10, 38% -297

MONEY LINE (Current Season) - Cleveland Guardians Road Games: 23-16, 59% +211 Athletics Home Games: 21-19, 52% -347 MONEY LINE (PAST 30 DAYS) - Cleveland Guardians Road Games: 8-6, 57% -77 Athletics Home Games: 9-7, 56% -19

OVER-UNDER RECORD (Current Season) - Cleveland Guardians Road Games: 15-15, 50% -150 Athletics Home Games: 20-18, 53% + 20 OVER-UNDER RECORD (PAST 30 DAYS) - Cleveland Guardians Road Games: 3-5, 38% -250 Athletics Home Games: 7-7, 50% -70

Click here to see AccuScore's pick for this game

Save 10% off membership by using coupon code: PREVIEW