The Buffalo Bills are a solid favorite with a 74.0% chance to beat the San Francisco 49ers. James Cook is projected for 73.0 rushing yards and a 45.0% chance of having at least 1 rushing TD. In the 26.0% of simulations where San Francisco 49ers wins, Brock Purdy averages 1.02 TD passes vs 0.49 interceptions, while in losses he has a ratio of 0.66 TDs to 1.01 interceptions. Christian McCaffrey averages 102.0 rushing yards and 0.84 rushing TDs when San Francisco 49ers wins and 62.0 yards and 0.31 TDs in losses. The Buffalo Bills has a 73.0% chance of forcing more turnovers than they commit. Positive turnover margin helps them win 85.0% of the time.
CURRENT SEASON: We advise relying on these trends after the first 3 weeks of the season.
| San Francisco 49ers | ATS RECORD | Buffalo Bills | ATS RECORD | ATS EDGE |
|---|
| All Games | 4-8-0 | All Games | 8-3-1 | No Edge |
| Road Games | 10-50-00 | Home Games | 4-1-0 | No Edge |
| When Underdog | 0-2-0 | When Favored | 7-2-1 | No Edge |
| Non-Division Opp | 3-5-0 | Non-Division Opp | 6-2-1 | No Edge |
| Opp .500+ Record | 2-4-0 | Opp Under .500 | 5-2-0 | No Edge |
LAST SEASON: We advise factoring for these trends for the first 3 to 6 weeks of the Current Season.
| San Francisco 49ers | ATS RECORD | Buffalo Bills | ATS RECORD | ATS EDGE |
|---|
| All Games | 9-10-1 | All Games | 8-10-1 | No Edge |
| Road Games | 60-30-10 | Home Games | 5-6-1 | No Edge |
| When Underdog | 0-0-0 | When Favored | 7-9-0 | No Edge |
| Non-Division Opp | 6-8-0 | Non-Division Opp | 5-7-1 | No Edge |
| Opp .500+ Record | 72-99-5 | Opp .500+ Record | 83-55-14 | No Edge |
OVER-UNDER TRENDS
| San Francisco 49ers | O-U-P RECORD | Buffalo Bills | O-U-P RECORD | O-U EDGE |
|---|
| All Totals (O-U-P) | 7-5-0 | All Totals (O-U-P) | 8-4-0 | OVER |
| On Road | 4-2-0 | At Home | 6-0-0 | OVER |
| All Totals Last Season | 10-9-1 | All Totals Last Season | 8-11-0 | UNDER |
| On Road Last Season | 4-6-0 | At Home Last Season | 5-6-0 | UNDER |
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